Randomized Controlled Trial of the Impact of Treating Moderately Malnourished Women in Pregnancy

Globally, there is a lack of agreement and global guidelines on how to diagnose or treat moderate malnutrition during pregnancy. In addition, the benefits of treatment of moderate malnutrition during pregnancy remain undocumented. To respond to this gap in evidence-based treatment protocols, FANTA initiated a study in collaboration with its partner, Washington University in St. Louis. The randomized controlled clinical trial tested whether providing a fortified flour (CSB+) with a multiple micronutrient tablet (UNIMMAP) or providing ready-to-use supplementary food (RUSF) would improve maternal weight gain and increase birth weight and length outcomes compared to the current standard of care in Malawi (CSB+ with iron-folic acid supplementation) when provided to pregnant women with moderate malnutrition. Overall, the results were similar across treatment arms. However, women who received RUSF had the highest mean weight gain from the time they began treatment until their final weight measurement, and the incidence of underweight among newborns was lowest among the infants born to women who received CSB+ with IFA.

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